Pathologically, MS is characterized by death of oligodendrocytes, the cells engaged primarily in production of myelin, thereby myelin loss and presence of macrophages filled with degradation end-products.
The disability of such a productive population is the extra-motivation behind the efforts to understand and cure MS. Some enjoy a prolonged remission while others may fare poorly (1). Duration and symptoms of active disease vary greatly from patient to patient. MS is characterized by remission and exacerbations. Approximately 400,000 MS patients have been recorded in the USA and about 2.5 million worldwide, with an estimated incidence of 10,000 in the United States (1). Multiple sclerosis (MS) is the most prevalent neurological disorder diagnosed in young adults, although no age group is exempt. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters. Results: IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively).Ĭonclusions: Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. All patients were diagnosed with MS according to the criteria of McDonald. Materials and methods: Thirty-five RRMS patients (15 males and 20 females median age 42 (20-55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females median age 37 (21-60) years) were included in this study.
The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS).
However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Introduction: Oligodendrocytes need iron in processes of energy generation and myelination.
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